Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception
نویسندگان
چکیده
منابع مشابه
Denervation of the lacrimal gland.
THE surgical treatment of epiphora is now well established and on the whole satisfactory. A success rate of almost 90 per cent. can be expected for the operation of dacryocystorhinostomy (Stallard, 1950). There still remains a considerable number of cases where the puncta or canaliculi are strictured or absent, where the lacrimal sac is absent or grossly damaged, or where the inner canthus is s...
متن کاملLacrimal Gland, Ocular Surface, and Dry Eye
1Pharmacology & Pharmaceutical Sciences, USC Eye Institute, University of Southern California, Los Angeles, CA, USA 2Pharmacology and Pharmacotherapy, Ophthalmology, University of Szeged, Szeged, Hungary 3Ophthalmology, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China 4Singapore Eye Research Institute, Singapore 5Department of Ophthalmology, Yong Loo Lin School of Me...
متن کاملReview: The Lacrimal Gland and Its Role in Dry Eye.
The human tear film is a 3-layered coating of the surface of the eye and a loss, or reduction, in any layer of this film may result in a syndrome of blurry vision and burning pain of the eyes known as dry eye. The lacrimal gland and accessory glands provide multiple components to the tear film, most notably the aqueous. Dysfunction of these glands results in the loss of aqueous and other produc...
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Exocrine gland-secreting peptides (ESPs) are a protein family involved in the pheromonal communication of rodents. ESP1 is a lacrimal peptide synthesized by the extraorbital glands of males of specific mouse strains that modulates the sexual behavior in females. Reportedly, BALB/c males, that produce high level of ESP1 in the tear fluid, were shown to enhance the lordosis behavior in C57BL/6 fe...
متن کاملPACAP suppresses dry eye signs by stimulating tear secretion
Dry eye syndrome is caused by a reduction in the volume or quality of tears. Here, we show that pituitary adenylate cyclase-activating polypeptide (PACAP)-null mice develop dry eye-like symptoms such as corneal keratinization and tear reduction. PACAP immunoreactivity is co-localized with a neuronal marker, and PACAP receptor (PAC1-R) immunoreactivity is observed in mouse infraorbital lacrimal ...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2018
ISSN: 1552-5783
DOI: 10.1167/iovs.18-25267